ENTRY       EC 4.6.1.3
NAME        3-Dehydroquinate synthase
CLASS       Lyases
            Phosphorus-oxygen lyases
SYSNAME     3-Deoxy-arabino-heptulosonate-7-phosphate phosphate-lyase
            (cyclyzing)
REACTION    2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate = 
            3-Dehydroquinate + Orthophosphate
SUBSTRATE   2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate
PRODUCT     3-Dehydroquinate
            Orthophosphate
COFACTOR    Cobalt
COMMENT     Requires Co2+. The hydrogen atoms on C-7 of the substrate are
            retained on C-2 of the product.
PATHWAY     PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
MOTIF       PS: PS00104  [LIVM]-x(2)-G-N-[SA]-G-T-[STA]-x-R-x-[LIVM]-x-[GSTA]
            PS: PS00885  [KR]-x-[KH]-E-[CT]-[DNE]-R-[LIVM]-x-[STA]-[LIVM]-x(2)-
                         E-[LIVM]-x-[KR]-[LIVMF]-G
            PS: PS01028  D-[LIVM]-[DE]-[LIVN]-x(18,20)-[LIVM](2)-x-[SC]-[NH]-H-D
            PS: PS01128  [KR]-x(2)-E-x(3)-[LIVMF]-x(8,12)-[LIVMF](2)-[SA]-x-
                         G(3)-x-[LIVMF]
GENES       MJA: MJ0407(nadA)
            MTH: MTH1827
            ECO: b3389(aroB)
            HIN: HI0208(aroB)
            HPY: HP0283(aroB) HP1356(nadA)
            BSU: aroB nadA
            SYN: sll0622(nadA) slr2130(aroB)
            SCE: YDR127W(ARO1)
DBLINKS     University of Geneva ENZYME DATA BANK: 4.6.1.3
            WIT (What Is There) Metabolic Reconstruction: 4.6.1.3
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