ENTRY       EC 4.1.3.27
NAME        Anthranilate synthase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     Chorismate pyruvate-lyase (amino-accepting)
REACTION    Chorismate + L-Glutamine = Anthranilate + Pyruvate + L-Glutamate
SUBSTRATE   Chorismate
            L-Glutamine
            NH3
PRODUCT     Anthranilate
            Pyruvate
            L-Glutamate
COMMENT     In some organisms, this enzyme is part of a multifunctional
            protein together with one or more other components of the system
            for biosymthesis of tryptophan (EC 2.4.2.18, 4.1.1.48, 4.2.1.20,
            5.3.1.24). The native enzyme in the complex uses either glutamine
            or, less efficiently, NH3. The enzyme separated from the complex
            uses NH3 only.
            Glutamine amidotransferase domian (type G) has SH protease-
            like catalytic residues.
PATHWAY     PATH: MAP00130  Ubiquinone biosynthesis
            PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
MOTIF       PS: PS00442  [PAS]-[LIVMFYT]-[LIVMFY]-G-[LIVMFY]-C-[LIVMFYN]-G-x-
                         [QE]-x-[LIVMFA]
            PS: PS00614  [LIVMFY]-[LIVMC]-x-E-[LIVMFYC]-K-[KRSP]-[ATK]-S-P-[ST]-
                         x(3)-[LIVMFYST]
GENES       MJA: MJ0234(trpD) MJ0238(trpG) MJ1075(trpE)
            MTH: MTH1655(trpE) MTH1656(trpG)
            ECO: b1263(trpD) b1264(trpE)
            HIN: HI1171(trpG) HI1387(trpE)
            HPY: HP1282(trpE)
            BSU: trpE
            SYN: slr0055(trpG) slr0738(trpE) slr1979(trpE)
            SCE: YER090W(TRP2) YKL211C(TRP3)
STRUCTURES  PDB: 1CSM  
DBLINKS     University of Geneva ENZYME DATA BANK: 4.1.3.27
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.27
///