ENTRY       EC 4.1.1.50
NAME        Adenosylmethionine decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     S-Adenosyl-L-methionine carboxy-lyase
REACTION    S-Adenosyl-L-methionine =
            (5-Deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
SUBSTRATE   S-Adenosyl-L-methionine
PRODUCT     (5-Deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt
            CO2
COFACTOR    Pyruvate
COMMENT     The E. coli enzyme contains a pyruvoyl group.
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
DISEASE     MIM: 180980  S-adenosylmethionine decarboxylase-1
GENES       ECO: b0120(speD)
            SCE: YOL052C(SPE2)
            HSA: AMD1(Hs.75744) AMD2(AMD)
DBLINKS     University of Geneva ENZYME DATA BANK: 4.1.1.50
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.50
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