ENTRY EC 3.6.1.38
NAME Ca2+-transporting ATPase
Calcium pump
CLASS Hydrolases
Acting on acid anhydrides
In phosphorus-containing anhydrides
SYSNAME ATP phosphohydrolase (Ca2+ -transporting)
REACTION ATP + H2O = ADP + Orthophosphate
SUBSTRATE ATP
H2O
PRODUCT ADP
Orthophosphate
COFACTOR Ca2+
Vanadate
COMMENT Hydrolysis of ATP is coupled with the transport of Ca2+ ions.
The enzyme from the plasma membrane of eucaryotes differs from
that found in sarcoplasmic reticulum in that it is activated by
calmodulin, is sensitive to low concentrations of vanadate, and
is of higher molecular mass (150 kDa). Formerly included with
EC 3.6.1.3.
DISEASE MIM: 108731 ATPase, Ca++ transporting, plasma membrane, 1
MIM: 108732 ATPase, Ca++ transporting, plasma membrane, 4
MIM: 108733 ATPase, Ca++ transporting, plasma membrane, 2
MIM: 108740 ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2
MIM: 300014 ATPase, Ca++ transporting, plasma membrane 3
MOTIF PS: PS00154 D-K-T-G-T-[LIVM]-[TI]
GENES SYN: sll0672(pacL)
SCE: YAL026C(PMC1) YDR093W(DRS2) YER166W(SYGP-ORF7) YGL006W(PCA1)
YGL167C(PMR1)
HSA: ATP2A1(ATP2A) ATP2A2(ATP2B) ATP2B2(PMCA2) ATP2B3(PMCA3)
ATP2B4(PMCA4)
DBLINKS University of Geneva ENZYME DATA BANK: 3.6.1.38
WIT (What Is There) Metabolic Reconstruction: 3.6.1.38
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