ENTRY       EC 3.6.1.1
NAME        Inorganic pyrophosphatase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     Pyrophosphate phosphohydrolase
REACTION    Pyrophosphate + H2O = 2 Orthophosphate
SUBSTRATE   Pyrophosphate
            H2O
PRODUCT     Orthophosphate
COFACTOR    Metal
COMMENT     Specificity varies with the source and with the activating metal
            ion. The enzyme from some sources may be identical with
            EC 3.1.3.1. or 3.1.3.9.
            (EC 3.1.3.1 Alkaline phosphatase)
            (EC 3.1.3.9 Glucose-6-phophatase)
PATHWAY     PATH: MAP00190  Oxidative phosphorylation
DISEASE     MIM: 179030  Inorganic pyrophosphatase
MOTIF       PS: PS00387  D-[SGN]-D-[PE]-[LIVM]-D-[LIVMGC]
GENES       MTH: MTH263
            ECO: b4226(ppa)
            HIN: HI0124(ppa)
            HPY: HP0620
            MGE: MG351(ppa)
            MPN: G12_orf184(ppa)
            SYN: slr1622(ppa)
            SCE: YBR011C(IPP1) YMR267W(IPP2)
            HSA: PP
STRUCTURES  PDB: 1FAJ  1IGP  1INO  1PYP  1YPP  2EIP  2PRD  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.6.1.1
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.1
            SCOP (Structural Classificaion of Proteins): 3.6.1.1
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