ENTRY       EC 3.5.5.5
NAME        Arylacetonitrilase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In nitriles
SYSNAME     Arylacetonitrile aminohydrolase
REACTION    4-Chlorophenylacetonitrile + 2 H2O = 4-Chlorophenylacetate + NH3
SUBSTRATE   4-Chlorophenylacetonitrile
            H2O
            4-Substituted phenylacetonitrile
            Thien-2-ylacetonitrile
            Tolylacetonitrile
PRODUCT     4-Chlorophenylacetate
            NH3
            4-Substituted phenylacetate
            Thien-2-ylacetate
            Tolylacetate
COFACTOR    Thiol compound
COMMENT     Requires thiol compounds. Also hydrolyses other 4-substituted
            phenylacetonitriles, thien-2-ylacetonitrile, tolylacetonitriles,
            and, more slowly, benzyl cyanide.
PATHWAY     PATH: MAP00460  Cyanoamino acid metabolism
DBLINKS     University of Geneva ENZYME DATA BANK: 3.5.5.5
            WIT (What Is There) Metabolic Reconstruction: 3.5.5.5
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