ENTRY       EC 3.5.4.4
NAME        Adenosine deaminase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amidines
SYSNAME     Adenosine aminohydrolase
REACTION    Adenosine + H2O = Inosine + NH3
SUBSTRATE   Adenosine
            H2O
PRODUCT     Inosine
            NH3
INHIBITOR   Nebularine
            6-Hydroxyl-1,6-dihydropurine ribonucleoside
COMMENT     Inhibited by Nebularine and 6-hydroxyl-1,6-dihydropurine
            ribonucleoside (Science (1989) 243, 1591-1593).
PATHWAY     PATH: MAP00230  Purine metabolism
DISEASE     MIM: 102700  Adenosine deaminase; Severe combined immunodeficiency
                         due to ADA deficiency (3); Hemolytic anemia due to ADA
                         excess (1)
MOTIF       PS: PS00485  S-[LIVM]-[NS]-T-D-D-P
GENES       ECO: b1623(add)
            SCE: YNL141W(N1208)
            HSA: ADA(Hs.1217)
STRUCTURES  PDB: 2ADA  1ADD  1FKW  1FKX  1UIO  1UIP  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.5.4.4
            WIT (What Is There) Metabolic Reconstruction: 3.5.4.4
            SCOP (Structural Classificaion of Proteins): 3.5.4.4
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