ENTRY       EC 3.1.3.9
NAME        Glucose-6-phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     D-Glucose-6-phosphate phosphohydrolase
REACTION    D-Glucose 6-phosphate + H2O = D-Glucose + Orthophosphate
SUBSTRATE   D-Glucose 6-phosphate
            H2O
PRODUCT     D-Glucose
            Orthophosphate
COMMENT     Wide distribution in animal tissues. Also catalyses potent
            transphosphorylations from carbamoyl phosphate, hexose phosphates,
            pyrophosphate, phosphoenolpyruvate and nucleoside di- and tri-
            phosphates, to D-glucose, D-mannose, 3-methyl-D-glucose or
            2-deoxy-D-glucose (cf. EC 2.7.1.62, 2.7.1.79 and 3.9.1.1).
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00052  Galactose metabolism
            PATH: MAP00500  Starch and sucrose metabolism
DISEASE     MIM: 232200  Glucose-6-phosphatase; Glycogen storage disease I (3)
GENES       HSA: G6PT(Hs.242)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.3.9
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.9
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