ENTRY       EC 3.1.3.57
NAME        Inositol-1,4-bisphosphate 1-phosphatase
            Inositol-polyphosphate 1-phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     D-myo-Inositol-1,4-bisphosphate 1-phosphohydrolase
REACTION    D-myo-Inositol 1,4-bisphosphate + H2O = D-myo-Inositol 4-phosphate
            + Orthophosphate
SUBSTRATE   D-myo-Inositol 1,4-bisphosphate
            H2O
            1D-myo-Inositol 1,3,4-trisphosphate
PRODUCT     D-myo-Inositol 4-phosphate
            Orthophosphate
            1D-myo-Inositol 3,4-bisphosphate
COMMENT     The enzyme acts on inositol 1,4-bisphosphate and inositol
            1,3,4-trisphosphate (forming inositol 3,4-bisphosphate) with
            similar Vmax for both substrates, but with a five times higher
            affinity for the bisphosphate. Does not act on inositol
            1-phosphate, inositol 1,4,5-trisphosphate or inositol 1,3,4,5-
            tetrakisphosphate.
PATHWAY     PATH: MAP00562  Inositol phosphate metabolism
DISEASE     MIM: 147263  Inositol polyphosphate 1-phosphatase
MOTIF       PS: PS00629  [FW]-x(0,1)-[LIVM]-D-P-[LIVM]-D-[SG]-T-x(2)-[FY]-x-
                         [HKRNTY]
            PS: PS00630  W-D-x(2)-[GA](2)-x-[LIVMANC]-[LIVMA](2)-x(3,4)-[GA](2)
STRUCTURES  PDB: 1INP  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.3.57
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.57
            SCOP (Structural Classificaion of Proteins): 3.1.3.57
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