ENTRY       EC 3.1.3.56
NAME        Inositol-1,4,5-trisphosphate 5-phosphatase
            Inositol trisphosphate phosphomonoesterase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     D-myo-Inositol-1,4,5-trisphosphate 5-phosphohydrolase
REACTION    D-myo-Inositol 1,4,5-trisphosphate + H2O =
            D-myo-Inositol 1,4-bisphosphate + Orthophosphate
SUBSTRATE   D-myo-Inositol 1,4,5-trisphosphate
            H2O
            1D-myo-Inositol 1,3,4,5-tetrakisphosphate
PRODUCT     D-myo-Inositol 1,4-bisphosphate
            Orthophosphate
            1D-myo-Inositol 1,3,4-trisphosphate
COMMENT     Type I enzyme (but not type II enzyme) also hydrolyses inositol
            1,3,4,5-tetrakisphosphate at the 5-position; neither enzyme acts
            on inositol 1,4-bisphosphate or inositol 1,3,4-trisphosphate.
            cf. EC 3.1.3.61.
PATHWAY     PATH: MAP00562  Inositol phosphate metabolism
DISEASE     MIM: 147264  Inositol polyphosphate-5-phosphatase, 75kD
GENES       HSA: INPP5A INPP5B
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.3.56
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.56
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