ENTRY       EC 3.1.3.48
NAME        Protein-tyrosine-phosphatase
            Phosphotyrosine phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     Protein-tyrosine-phosphate phosphohydrolase
REACTION    Protein tyrosine phosphate + H2O = Protein tyrosine +
            Orthophosphate
SUBSTRATE   Protein tyrosine phosphate
            H2O
PRODUCT     Protein tyrosine
            Orthophosphate
COMMENT     Dephosphorylates O-phosphotyrosine groups in phosphoproteins,
            such as the products of EC 2.7.1.112.
            Phosphoprotein phosphatase (cf. EC 3.1.3.16) is a group of enzymes
            removing the serine- or threonine-bound phosphate group.
DISEASE     MIM: 1154412.7.7.12:
            MIM: 116947  Cell division cycle 25A
            MIM: 151460  Protein tyrosine phosphatase, receptor-type, c
                         polypeptide
            MIM: 157680  Cell division cycle 25C
            MIM: 171500  Acid phosphatase 1, soluble
            MIM: 176886  Protein tyrosine phosphatase, receptor-type, gamma
                         polypeptide
            MIM: 176892  Protein kinase, cAMP-dependent, catalytic, beta
            MIM: 179590  Protein tyrosine phosphatase, receptor-type, f
                         polypeptide
            MIM: 230400  Galactose-1-phosphate uridyltransferase; Galactosemia
                         (3)
            MIM: 600714  Dual specificity phosphatase 1
            MIM: 601773  Protein tyrosine phosphatase, receptor type, N
MOTIF       PS: PS00383  [LIVMF]-H-C-x(2)-G-x(3)-[STC]-[STAG]-x-[LIVMFY]
            PS: PS00660  W-L-x(3)-[KR]-x-[LIVM]-x(2)-[QH]-x(0,1)-[LIVMF]-x(6,7)-
                         [LIVMF]-x(2,4)-[KR]-F-[FY]-x(2)-[DN]
            PS: PS00661  [HY]-x(9)-[DENQSTV]-[SA]-x(3)-[FY]-[LIVM]-x(2)-A-x(2)-
                         L-x(2)-Y-G-[LIVM]-[DENQST]-[LIVMFY]
            PS: PS00740  G-x(12)-G-x(2)-A-x-L-x(4)-[LIVM]-x(6,7)-C-[LIVM]-x-F
            PS: PS50001  Src homology 2 (SH2) domain profile
GENES       ECO: b0982(yccY) b2061(wzb)
            BSU: yfkJ ywlE(ipc-31d)
            SYN: slr0328
            SCE: YBR276C(YBR2013) YDL230W(PTP1) YER075C YFR028C(CDC14) YIL113W
                 YIR026C(YVH1) YMR036C(MIH1) YNL053W(MSG5) YOR208W(PTP2)
                 YPR073C(LTP1)
STRUCTURES  PDB: 1AYA  1YFO  1AYB  1AYC  1AYD  1PHR  1PTT  1PTU  1PTV  1VHR  
                 1YPT  1YTN  1YTS  1YTW  2HNP  2HNQ  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.3.48
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.48
            SCOP (Structural Classificaion of Proteins): 3.1.3.48
///