ENTRY       EC 3.1.3.11
NAME        Fructose-bisphosphatase
            Hexosediphosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     D-Fructose-1,6-bisphosphate 1-phosphohydrolase
REACTION    D-Fructose 1,6-bisphosphate + H2O = D-Fructose 6-phosphate +
            Orthophosphate;
            Sedoheptulose 1,7-bisphosphate + H2O =
            Sedoheptulose 7-phosphate + Orthophosphate
SUBSTRATE   D-Fructose 1,6-bisphosphate
            Sedoheptulose 1,7-bisphosphate
            H2O
PRODUCT     D-Fructose 6-phosphate
            Sedoheptulose 7-phosphate
            Orthophosphate
COMMENT     The animal enzyme also acts on sedoheptulose 1,7-bisphosphate
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00030  Pentose phosphate cycle
            PATH: MAP00051  Fructose and mannose metabolism
            PATH: MAP00710  Carbon fixation
DISEASE     MIM: 229700  Fructose-bisphosphatase 1; Fructose-bisphosphatase
                         deficiency (1)
MOTIF       PS: PS00124  [AG]-[RK]-L-x(1,2)-[LIV]-[FY]-E-x(2)-P-[LIVM]-[GSA]
GENES       ECO: b4232(fbp)
            HIN: HI1645(fbp)
            HPY: HP1385
            BSU: fbp(yydE)
            SYN: slr0952(fbp)
            SCE: YLR377C(FBP1)
            HSA: FBP1(FBP)
STRUCTURES  PDB: 2FBP  1SPI  1RDZ  1RDY  1RDX  1FTA  3FBP  1FPL  4FBP  1FPJ  
                 1FPI  1FPG  1FPF  1FPE  1FPD  1FPB  1FBP  1FBH  1FBG  1FBF  
                 1FBE  1FBD  1FBC  1FRP  1FPK  5FBP  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.3.11
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.11
            SCOP (Structural Classificaion of Proteins): 3.1.3.11
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