ENTRY       EC 3.1.3.1
NAME        Alkaline phosphatase
            Alkaline phosphomonoesterase
            Phosphomonoesterase
            Glycerophosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     Orthophosphoric-monoester phosphohydrolase (alkaline optimum)
REACTION    an Orthophosphoric monoester + H2O = an Alcohol + Orthophosphate
SUBSTRATE   Orthophosphoric monoester
            H2O
PRODUCT     Alcohol
            Orthophosphate
COMMENT     Wide specificity. Also catalyses transphosphorylations. The
            human placental enzyme is a zinc protein. Some enzymes hydrolyse
            pyrophosphate (cf. EC 3.6.1.1).
            (EC 3.6.1.1 Inorganic pyrophosphatase)
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
            PATH: MAP00790  Folate biosynthesis
            PATH: MAP00930  Metabolism of xenobiotics
DISEASE     MIM: 171740  Alkaline phosphatase, intestinal
            MIM: 171760  Alkaline phosphatase, liver/bone/kidney;
                         Hypophosphatasia, infantile, 241500 (3);
                         ?Hypophosphatasia, adult, 146300 (1)
            MIM: 171800  Alkaline phosphatase, placental (Regan isozyme)
            MIM: 171810  Alkaline phosphatase, placental-like 2
MOTIF       PS: PS00123  [IV]-x-D-S-[GAS]-[GASC]-[GAST]-[GA]-T
GENES       ECO: b0383(phoA)
            BSU: phoA(phoAIV) phoB(phoAIII) phoD(ycbS)
            SYN: sll0222(phoA) sll0654 slr1343
            SCE: YDR481C(PHO8)
            HSA: ALPI ALPL(HOPS) ALPP(Hs.73847)
STRUCTURES  PDB: 1AJA  1AJB  1AJC  1AJD  1ALH  1ALI  1ALJ  1ALK  1ANI  2ANH  
                 1ANJ  1HQA  1URA  1URB  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.3.1
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.1
            SCOP (Structural Classificaion of Proteins): 3.1.3.1
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