ENTRY       EC 2.7.7.46
NAME        Gentamicin 2''-nucleotidyltransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     NTP:gentamicin 2''-nucleotidyltransferase
REACTION    Nucleoside triphosphate + Gentamicin = Pyrophosphate +
            2''-Nucleotidylgentamicin
SUBSTRATE   Nucleoside triphosphate
            Gentamicin
            ATP
            dATP
            CTP
            ITP
            GTP
            Kanamycin
            Tobramycin
            Sisomicin
PRODUCT     Pyrophosphate
            2''-Nucleotidylgentamicin
            2''-Nucleotidylkanamycin
            2''-Nucleotidyltobramycin
            2''-Nucleotidylsisomicin
COMMENT     ATP, dATP, CTP, ITP and GTP can act as donors; kanamycin,
            tobramycin and sisomicin can also act as acceptors. The
            nucleotidyl residue is transferred to the 2-hydroxyl of
            the 3-amino-3-deoxy-D-glucose moiety in the antibiotic.
DBLINKS     University of Geneva ENZYME DATA BANK: 2.7.7.46
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.46
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