ENTRY       EC 2.7.4.6
NAME        Nucleoside-diphosphate kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a phosphate group as acceptor
SYSNAME     ATP:nucleoside-diphosphate phosphatransferase
REACTION    ATP + Nucleoside diphosphate = ADP + Nucleoside triphosphate
SUBSTRATE   ATP
            Nucleoside diphosphate
            ADP
            GDP
            UDP
            IDP
            CDP
            XDP
            dATP
            GTP
            dGTP
            UTP
            dUTP
            ITP
            dITP
            CTP
            dCTP
            XTP
            dXTP
PRODUCT     ADP
            Nucleoside triphosphate
            dADP
            GDP
            dGDP
            UDP
            dUDP
            IDP
            dIDP
            CDP
            dCDP
            XDP
            dXDP
            ATP
            GTP
            UTP
            ITP
            CTP
            XTP
COMMENT     Many nucleoside diphosphate can act as acceptors, while many
            ribo- and deoxyribonucleoside triphosphate can act as donors.
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00240  Pyrimidine metabolism
DISEASE     MIM: 156490  Non-metastatic cells 1, protein (NM23A) expressed in
            MIM: 156491  Non-metastatic cells 2, protein (NM23) expressed in
            MIM: 601818  Non-metastatic cells 4, protein expressed in
MOTIF       PS: PS00469  N-x(2)-H-G-S-D-[SA]-[LIVMPN]
GENES       MJA: MJ1265(ndk)
            ECO: b2518(ndk)
            HIN: HI0876(ndk)
            HPY: HP0198
            BSU: ndk
            SYN: sll1852(ndk)
            SCE: YKL067W(NDK1)
STRUCTURES  PDB: 1KDN  1NDL  1NDP  1NUE  2NCK  1LEO  1NCL  1NDC  1NDK  1NSQ  
                 1NSP  1NHK  1NLK  1NPK  1NSK  
DBLINKS     University of Geneva ENZYME DATA BANK: 2.7.4.6
            WIT (What Is There) Metabolic Reconstruction: 2.7.4.6
            SCOP (Structural Classificaion of Proteins): 2.7.4.6
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