ENTRY       EC 2.7.1.37
NAME        Protein kinase
            Phospharylase b kinase kinase
            Glycogen synthase a kinase
            Hydroxyalkyl-protein kinase
            Serine(threonine) protein kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:protein phosphotransferase
REACTION    ATP + a Protein = ADP + a Phosphoprotein
SUBSTRATE   ATP
            Protein
PRODUCT     ADP
            Phosphoprotein
INHIBITOR   Debromoaplysiatoxin
            Bryostatins
            Teleocidin B-1
            12-O-Tetradecanoylphorbol 13-acetate
COMMENT     A group of enzymes which are under review by NC-IUBMB.
            Other present entries are EC 2.7.1.38, 2.7.1.70, 2.7.1.99,
            2.7.1.109-112, 2.7.1.115-6, 2.7.1.123-6, 2.7.1.135 and 2.7.1.141.
            Some enzymes are activated by cyclic GMP, but not by cyclic AMP,
            and some enzymes by neither.
DISEASE     MIM: 115440  Casein kinase-2, alpha-1 polypeptide
            MIM: 164731  Murine thymoma viral (v-akt) homolog-2; Ovarian
                         carcinoma, 167000 (2)
            MIM: 311550  PCTAIRE protein kinase 1
MOTIF       PS: PS00107  [LIV]-G-{P}-G-{P}-[FYWMGSTNH]-[SGA]-{PW}-[LIVCAT]-{PD}-
                         x-[GSTACLIVMFY]-x(5,18)-[LIVMFYWCSTAR]-[AIVP]-
                         [LIVMFAGCKR]-K
            PS: PS00108  [LIVMFYC]-x-[HY]-x-D-[LIVMFY]-K-x(2)-N-[LIVMFYCT](3)
            PS: PS00888  [LIVM]-[VIC]-x(2)-G-[DENQTA]-x-[GA]-x(2)-[LIVMFY](4)-
                         x(2)-G
            PS: PS00889  [LIVMF]-G-E-x-[GAS]-[LIVM]-x(5,11)-R-[STAQ]-A-x-
                         [LIVMA]-x-[STACV]
            PS: PS01101  C-P-x-[LIVMY]-x-C-x(5)-L-P-[LIVMC]-G-x(9)-V-[KR]-x(2)-
                         C-P-x-C
            PS: PS50003  PH domain profile
            PS: PS50004  C2-domain profile
            PS: PS50011  Protein kinase domain profile
            PS: PS50017  Death domain profile
GENES       MTH: MTH1485 MTH283
            MPN: K04_orf389
            SYN: sll1575 slr0152 slr1225(pknA) slr1443(pknA)
            SCE: YGL019W(CKB1) YHR205W(SCH9) YIL035C(CKA1) YJL164C(TPK1)
                 YKL166C(TPK3) YOR039W(CKB2) YOR061W(CKA2) YPL203W(TPK2)
            HSA: PRKAR1A(TSE1) PRKAR1B(Hs.1519) PRKAR2A(PRKAR2)
                 PRKAR2B(PRKAR2) PRKCA(PKCA) PRKCD(Hs.458) PRKCE PRKCG(PKCG)
                 PRKCH(PKC-L) PRKCM(PKCM) PRKCQ(Hs.89615) PRKCSH(G19P1)
                 PRKCZ(Hs.78793)
STRUCTURES  PDB: 1YDS  1YDR  1TBI  1RGS  1HCL  1HCK  1YDT  1CDK  1BPK  1ATP  
                 1APM  1APK  2APK  2BPK  2CPK  1CMK  1CTP  
DBLINKS     University of Geneva ENZYME DATA BANK: 2.7.1.37
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.37
            SCOP (Structural Classificaion of Proteins): 2.7.1.37
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