ENTRY       EC 2.7.1.21
NAME        Thymidine kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:thymidine 5'-phosphotransferase
REACTION    ATP + Thymidine = ADP + Thymidine 5'-phosphate
SUBSTRATE   ATP
            dGTP
            Thymidine
            Deoxythymidine
            Deoxyuridine
PRODUCT     ADP
            dGDP
            Thymidine 5'-phosphate
            Deoxythymidine 5'-phosphate
            Deoxyuridine 5'-phosphate
COMMENT     Deoxyuridine can also act as acceptor, and dGTP as a donor. The
            deoxypyrimidine kinase complex induced by Herpes simplex virus
            catalyses this reaction as well as those of EC 2.7.1.114,
            2.7.1.118 and 2.7.4.9.
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
DISEASE     MIM: 188300  Thymidine kinase-1
MOTIF       PS: PS00603  [GA]-x(1,2)-[DE]-x-Y-x-[STAP]-x-C-[NKR]-x-[CH]-
                         [LIVMFYWH]
GENES       ECO: b1238(tdk)
            HIN: HI0529(tdk)
            BSU: tdk
            MGE: MG034(tdk)
            MPN: B01_orf191(tdk)
            SYN: sll1751
            HSA: TK1(Hs.2033) TK2
STRUCTURES  PDB: 1KIN  
DBLINKS     University of Geneva ENZYME DATA BANK: 2.7.1.21
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.21
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