ENTRY       EC 2.7.1.120
NAME        Caldesmon kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:Caldesmon O-phosphotransferase
REACTION    ATP + Caldesmon = ADP + Caldesmon phosphate
SUBSTRATE   ATP
            Caldesmon
PRODUCT     ADP
            Caldesmon phosphate
EFFECTOR    Calcium
            Calmodulin
COMMENT     Requires Ca2+ and calmodulin. Phosphorylation abolishes the
            ability of the protein caldesmon to bind actin and inhibit ATPase.
            The enzyme appears to be identical with caldesmon; the reaction is
            an autophosphorylation.
DBLINKS     University of Geneva ENZYME DATA BANK: 2.7.1.120
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.120
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