ENTRY       EC 2.7.1.11
NAME        6-Phosphofructokinase
            Phosphohexokinase
            Phosphofructokinase 1
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:D-fructose-6-phosphate 1-phosphotransferase
REACTION    ATP + D-Fructose 6-phosphate = ADP + D-Fructose 1,6-bisphosphate;
            UTP + D-Fructose 6-phosphate = UDP + D-Fructose 1,6-bisphosphate;
            CTP + D-Fructose 6-phosphate = CDP + D-Fructose 1,6-bisphosphate;
            ITP + D-Fructose 6-phosphate = IDP + D-Fructose 1,6-bisphosphate;
            ATP + D-Tagatose 6-phosphate = ADP + D-Tagatose 1,6-bisphosphate;
            UTP + D-Tagatose 6-phosphate = UDP + D-Tagatose 1,6-bisphosphate;
            CTP + D-Tagatose 6-phosphate = CDP + D-Tagatose 1,6-bisphosphate;
            ITP + D-Tagatose 6-phosphate = IDP + D-Tagatose 1,6-bisphosphate;
            ATP + Sedoheptulose 7-phosphate = ADP +
            Sedoheptulose 1,7-bisphosphate;
            UTP + Sedoheptulose 7-phosphate = UDP +
            Sedoheptulose 1,7-bisphosphate;
            CTP + Sedoheptulose 7-phosphate = CDP +
            Sedoheptulose 1,7-bisphosphate;
            ITP + Sedoheptulose 7-phosphate = IDP +
            Sedoheptulose 1,7-bisphosphate
SUBSTRATE   ATP
            UTP
            CTP
            ITP
            D-Fructose 6-phosphate
            D-Tagatose 6-phosphate
            Sedoheptulose 7-phosphate
PRODUCT     ADP
            UDP
            CDP
            IDP
            D-Fructose 1,6-bisphosphate
            D-Tagatose 1,6-bisphosphate
            Sedoheptulose 1,7-bisphosphate
EFFECTOR    ADP
            GDP
            Phosphoenolpyruvate
COMMENT     D-Tagatose 6-phosphate and sedoheptulose 7-phosphate can act as
            acceptors; UTP, CTP, and ITP can act as donors. Not identical with
            EC 2.7.1.105 (EC 2.7.1.105 6-Phosphofructo-2-kinase)
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00030  Pentose phosphate cycle
            PATH: MAP00051  Fructose and mannose metabolism
            PATH: MAP00052  Galactose metabolism
DISEASE     MIM: 171840  Phosphofructokinase, platelet type
            MIM: 171860  Phosphofructokinase, liver type; Hemolytic anemia due
                         to phosphofructokinase deficiency (1)
            MIM: 232800  Phosphofructokinase, muscle type; Glycogen storage
                         disease VII (3)
MOTIF       PS: PS00433  [RK]-x(4)-G-H-x-Q-[QR]-G-G-x(5)-D-R
            PS: PS00583  [AG]-G-x(0,1)-[GAP]-x-N-x-[STA]-x(6)-[GS]-x(9)-G
            PS: PS00584  [DNSK]-[PSTV]-x-[SAG](2)-[GD]-D-x(3)-[SAG]-[AG]-
                         [LIVMFY]-[LIVMSTAP]
GENES       ECO: b1723(pfkB) b3916(pfkA)
            HIN: HI0982(pfkA)
            BSU: pfk
            MGE: MG215(pfkA)
            MPN: H10_orf328(pfkA)
            SYN: sll0745(pfkA) sll1196(pfkA)
            SCE: YGR240C(PFK1) YMR205C(PFK2)
            HSA: PFKL(Hs.100005) PFKM(Hs.75160) PFKP(Hs.99910) PFKX
STRUCTURES  PDB: 1PFK  2PFK  3PFK  4PFK  6PFK  
DBLINKS     University of Geneva ENZYME DATA BANK: 2.7.1.11
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.11
            SCOP (Structural Classificaion of Proteins): 2.7.1.11
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