ENTRY       EC 2.7.1.1
NAME        Hexokinase
            Glucokinase
            Hexokinase type IV
            Hexokinase D
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:D-hexose 6-phosphotransferase
REACTION    ATP + D-Hexose = ADP + D-Hexose 6-phosphate;
            ITP + D-Hexose = IDP + D-Hexose 6-phosphate;
            dATP + D-Hexose = dADP + D-Hexose 6-phosphate;
            ATP + D-Glucose = ADP + D-Glucose 6-phosphate;
            ITP + D-Glucose = IDP + D-Glucose 6-phosphate;
            dATP + D-Glucose = dADP + D-Glucose 6-phosphate;
            ATP + D-Mannose = ADP + D-Mannose 6-phosphate;
            ITP + D-Mannose = IDP + D-Mannose 6-phosphate;
            dATP + D-Mannose = dADP + D-Mannose 6-phosphate;
            ATP + D-Fructose = ADP + D-Fructose 6-phosphate;
            ITP + D-Fructose = IDP + D-Fructose 6-phosphate;
            dATP + D-Fructose = dADP + D-Fructose 6-phosphate;
            ATP + D-Glucosamine = ADP + D-Glucosamine 6-phosphate;
            ITP + D-Glucosamine = IDP + D-Glucosamine 6-phosphate;
            dATP + D-Glucosamine = dADP + D-Glucosamine 6-phosphate;
            ATP + Sorbitol = ADP + Sorbitol 6-phosphate;
            ITP + Sorbitol = IDP + Sorbitol 6-phosphate;
            dATP + Sorbitol = dADP + Sorbitol 6-phosphate
SUBSTRATE   ATP
            ITP
            dATP
            D-Hexose
            D-Glucose
            D-Mannose
            D-Fructose
            D-Glucosamine
            Sorbitol
PRODUCT     ADP
            IDP
            dADP
            D-Hexose 6-phosphate
            D-Glucose 6-phosphate
            D-Mannose 6-phosphate
            D-Fructose 6-phosphate
            D-Glucosamine 6-phosphate
            Sorbitol 6-phosphate
COMMENT     D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine
            can act as acceptors; ITP and dATP can act as donors. The liver
            isoenzyme has sometimes been called glucokinase.
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00051  Fructose and mannose metabolism
            PATH: MAP00052  Galactose metabolism
            PATH: MAP00500  Starch and sucrose metabolism
            PATH: MAP00530  Aminosugars metabolism
DISEASE     MIM: 138079  Glucokinase (hexokinase-4); MODY, type 2, 125851 (3)
            MIM: 142570  Hexokinase 3 (white cell)
            MIM: 142600  Hexokinase-1; Hemolytic anemia due to hexokinase
                         deficiency (3)
            MIM: 601125  Hexokinase-2 (muscle)
MOTIF       PS: PS00378  [LIVM]-G-F-[TN]-F-S-[FY]-P-x(5)-[LIVM]-[DN]-x(3)-
                         [LIVM]-x(2)-W-T-K-x-F
GENES       SCE: YFR053C(HXK1) YGL253W(HXK2)
            HSA: HK1(Hs.75276) HK2 HK3(Hs.94397)
STRUCTURES  PDB: 1GLK  1HKG  2YHX  
DBLINKS     University of Geneva ENZYME DATA BANK: 2.7.1.1
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.1
            SCOP (Structural Classificaion of Proteins): 2.7.1.1
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