ENTRY       EC 2.5.1.19
NAME        3-Phosphoshikimate 1-carboxyvinyltransferase
            5-Enolpyruvylshikimate-3-phosphate synthase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     Phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-
            transferase
REACTION    Phosphoenolpyruvate + Shikimate 3-phosphate = Orthophosphate +
            5-O-(1-Carboxyvinyl)-3-phosphoshikimate
SUBSTRATE   Phosphoenolpyruvate
            Shikimate 3-phosphate
PRODUCT     Orthophosphate
            5-O-(1-Carboxyvinyl)-3-phosphoshikimate
INHIBITOR   Glyphosate
COMMENT     Shikimate is numbered so that the double bond is between C-1 and
            C-2, but some earlier papers numbered the ring in the reverse
            direction
            3D-structure of the enzyme from E.coli was determined at 3-A
            resolution (Stallings W.C.,et.al. Proc.Natl.Acad.Sci.USA (1991)
            88:5046-5050
PATHWAY     PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
MOTIF       PS: PS00104  [LIVM]-x(2)-G-N-[SA]-G-T-[STA]-x-R-x-[LIVM]-x-[GSTA]
            PS: PS00885  [KR]-x-[KH]-E-[CT]-[DNE]-R-[LIVM]-x-[STA]-[LIVM]-x(2)-
                         E-[LIVM]-x-[KR]-[LIVMF]-G
            PS: PS01028  D-[LIVM]-[DE]-[LIVN]-x(18,20)-[LIVM](2)-x-[SC]-[NH]-H-D
            PS: PS01128  [KR]-x(2)-E-x(3)-[LIVMF]-x(8,12)-[LIVMF](2)-[SA]-x-
                         G(3)-x-[LIVMF]
GENES       MJA: MJ0502
            MTH: MTH766
            ECO: b0908(aroA)
            HIN: HI1589(aroA)
            HPY: HP0401(aroA)
            BSU: aroE
            SYN: slr0444(aroA)
            SCE: YDR127W(ARO1)
DBLINKS     University of Geneva ENZYME DATA BANK: 2.5.1.19
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.19
///