ENTRY       EC 2.4.2.1
NAME        Purine-nucleoside phosphorylase
            Inosine phosphorylase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     Purine-nucleoside:orthophosphate ribosyltransferase
REACTION    Purine nucleoside + Orthophosphate = Purine +
            alpha-D-Ribose 1-phosphate
SUBSTRATE   Purine nucleoside
            Orthophosphate
PRODUCT     Purine
            alpha-D-Ribose 1-phosphate
COMMENT     Specificity not completely determined. Can also catalyse ribosyl-
            transferase reactions of the type catalysed by EC 2.4.2.5.
            (EC 2.4.2.5 Nucleoside ribosyltransferase)
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00240  Pyrimidine metabolism
            PATH: MAP00760  Nicotinate and nicotinamide metabolism
DISEASE     MIM: 164050  Nucleoside phosphorylase; Nucleoside phosphorylase
                         deficiency, immunodeficiency due to (3)
GENES       ECO: b4384(deoD)
            HIN: HI0518(deoD)
            HPY: HP1178(deoD)
            BSU: deoD pnp(yqkO)
            MGE: MG049(deoD)
            MPN: D09_orf238(deoD)
            HSA: NP(Hs.75514)
STRUCTURES  PDB: 1ECP  1PBN  1ULA  1ULB  
DBLINKS     University of Geneva ENZYME DATA BANK: 2.4.2.1
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.1
            SCOP (Structural Classificaion of Proteins): 2.4.2.1
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