ENTRY       EC 2.3.2.5
NAME        Glutaminyl-peptide cyclotransferase
            Glutaminyl-tRNA cyclotransferase
            Glutaminyl cyclase
CLASS       Transferases
            Acyltransferases
            Aminoacyltransferases
SYSNAME     L-Glutaminyl-peptide gamma-gluramyltransferase (cyclizing)
REACTION    L-Glutaminyl-peptide = 5-Oxoprolyl-peptide + NH3
SUBSTRATE   L-Glutaminyl-peptide
            Glutaminyl-tRNA
PRODUCT     5-Oxoprolyl-peptide
            NH3
            5-Oxoprolyl-tRNA
COMMENT     Involved in the formation of thyrotropin-releasing hormone and
            other biologically active peptides containing N-terminal
            pyroglutamyl residues. The enzyme from papaya also acts on
            glutaminyl-tRNA.
DBLINKS     University of Geneva ENZYME DATA BANK: 2.3.2.5
            WIT (What Is There) Metabolic Reconstruction: 2.3.2.5
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