ENTRY       EC 2.1.3.3
NAME        Ornithine carbamoyltransferase
            Citrulline phospharylase
            Ornithine transcarbamylase
CLASS       Transferases
            Transferring one-carbon groups
            Carboxyl- and carbamoyltransferases
SYSNAME     Carbamoyl-phosphate:L-ornithine carbamoyltransferase
REACTION    Carbamoyl phosphate + L-Ornithine = Orthophosphate + L-Citrulline
SUBSTRATE   Carbamoyl phosphate
            L-Ornithine
            Putrescine
            ATP
            NH3
            CO2
            Agmatine
            H2O
PRODUCT     Orthophosphate
            L-Citrulline
            Putrescine
            ADP
            Carbamoyl phosphate
            N-Carbamoylputrescine
            NH3
COMMENT     The plant enzyme also catalyses the reactions of EC 2.1.3.6,
            2.7.2.2 and 3.5.3.12, thus acting as putrescine synthase,
            converting agmatine and ornithine into putrescine and citrulline
            respectively.
            (EC 2.1.3.6 Putrescine carbamoyltransferase)
            (EC 2.7.2.2 Carbamate kinase)
            (EC 3.5.3.12 Agmatine deaminas)
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
            PATH: MAP00330  Arginine and proline metabolism
DISEASE     MIM: 311250  Ornithine transcarbamylase; Ornithine transcarbamylase
                         deficiency (3)
MOTIF       PS: PS00097  F-x-[EK]-x-S-[GT]-R-T
GENES       MJA: MJ0881(argF)
            MTH: MTH1446
            ECO: b0273(argF) b4254(argI)
            HIN: HI0596(argi/F)
            BSU: argF
            MPN: H10_orf273o(argI)
            SYN: sll0902(argF)
            SCE: YJL088W(ARG3)
            HSA: OTC(Hs.1842)
STRUCTURES  PDB: 1ORT  
DBLINKS     University of Geneva ENZYME DATA BANK: 2.1.3.3
            WIT (What Is There) Metabolic Reconstruction: 2.1.3.3
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