ENTRY       EC 2.1.1.98
NAME        Diphthine synthase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:2-(3-carboxy-3-aminopropyl)-L-histidine
            $ methyltransferase
REACTION    S-Adenosyl-L-methionine + 2-(3-Carboxy-3-aminopropyl)-L-histidine = 
            S-Adenosyl-L-homocysteine + 
            2-[3-Carboxy-3-(methylammonio)propyl]-L-histidine
SUBSTRATE   S-Adenosyl-L-methionine
            2-(3-Carboxy-3-aminopropyl)-L-histidine
PRODUCT     S-Adenosyl-L-homocysteine
            2-[3-Carboxy-3-(methylammonio)propyl]-L-histidine
COMMENT     2-[3-Carboxy-3-(methylammonio)propyl]-L-histidine and the
            corresponding dimethyl compound can also act as acceptors; the
            trimethylated product, diphthine, is converted into diphthamide by
            EC 6.3.2.22.
GENES       MJA: MJ1274
            MTH: MTH1874
            SCE: YLR172C(DPH5)
DBLINKS     University of Geneva ENZYME DATA BANK: 2.1.1.98
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.98
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