ENTRY       EC 2.1.1.89
NAME        Tetrahydrocolumbamine 2-O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:5,8,13,13a-tetrahydrocolumbamine
            $ 2-O-methyltransferase
REACTION    S-Adenosyl-L-methionine + 5,8,13,13a-Tetrahydrocolumbamine =
            S-Adenosyl-L-homocysteine + Tetrahydropalmatine
SUBSTRATE   S-Adenosyl-L-methionine
            5,8,13,13a-Tetrahydrocolumbamine
PRODUCT     S-Adenosyl-L-homocysteine
            Tetrahydropalmatine
COMMENT     Involved in the biosynthesis of the berberine alkaloids.
DBLINKS     University of Geneva ENZYME DATA BANK: 2.1.1.89
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.89
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