ENTRY       EC 2.1.1.77
NAME        Protein-L-isoaspartate(D-aspartate) O-methyltransferase
            Protein-L-isoaspartate O-methyltransferase
            Protein-beta-aspartate methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:protein-L-isoaspartate O-methyltransferase
REACTION    S-Adenosyl-L-methionine + Protein L-isoaspartate =
            S-Adenosyl-L-homocysteine + Protein L-isoaspartate methyl ester
SUBSTRATE   S-Adenosyl-L-methionine
            Protein L-isoaspartate
PRODUCT     S-Adenosyl-L-homocysteine
            Protein L-isoaspartate methyl ester
COMMENT     D-Aspartate (but not L-aspartate) residues in proteins can also
            act as acceptor. Previously also listed as EC 2.1.1.24.
DISEASE     MIM: 176851  Protein-L-isoaspartate (D-aspartate)
                         O-methyltransferase
GENES       MJA: MJ0134 MJ0172(pcm)
            MTH: MTH1414 MTH827
            ECO: b2743(pcm)
            HPY: HP0363
            HSA: PCMT1
DBLINKS     University of Geneva ENZYME DATA BANK: 2.1.1.77
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.77
///