ENTRY       EC 2.1.1.73
NAME        Site-specific DNA-methyltransferase (cytosine-specific )
            Modification methylase
            Restriction-Modification system
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
REACTION    S-Adenosyl-L-methionine + DNA cytosine = S-Adenosyl-L-homocysteine
            + DNA 5-methylcytosine
SUBSTRATE   S-Adenosyl-L-methionine
            DNA cytosine
            Deoxycytosine
PRODUCT     S-Adenosyl-L-homocysteine
            DNA 5-methylcytosine
            5-Methyl-2'-deoxycytidine
COMMENT     This is a large group of enzymes which, with enzymes of similar
            site specificity listed as EC 3.1.21.3, 4 or 5, form so-called
            "restriction-modification systems". A complelte listing of all
            the these enzymes has been produced by R.J.Roberts; this list is
            update annually.
MOTIF       PS: PS00094  [DENK]-x-[FLIV]-x(2)-[GSTC]-x-P-C-x(2)-[FYWLIM]-S
            PS: PS00095  [RKQGTF]-x(2)-G-N-[STAG]-[LIVMF]-x(3)-[LIVMT]-x(3)-
                         [LIVM]-x(3)-[LIVM]
GENES       MJA: MJ0563 MJ1200
            MTH: MTH495
            ECO: b1961(dcm)
            HIN: HI1041
            HPY: HP0051 HP0054 HP1121
            BSU: mtbP
            SYN: slr0214
STRUCTURES  PDB: 1MHT  3MHT  4MHT  
DBLINKS     University of Geneva ENZYME DATA BANK: 2.1.1.73
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.73
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