ENTRY EC 2.1.1.72
NAME Site-specific DNA-methyltransferase (adenine-specific)
Modification methylase
Restriction-Modification system
CLASS Transferases
Transferring one-carbon groups
Methyltransferases
REACTION S-Adenosyl-L-methionine + DNA adenine = S-Adenosyl-L-homocysteine
+ DNA 6-methylaminopurine
SUBSTRATE S-Adenosyl-L-methionine
DNA adenine
PRODUCT S-Adenosyl-L-homocysteine
DNA 6-methylaminopurine
COMMENT This is a large group of enzymes most of which, with enzymes of
similar site specificity listed as EC 3.1.21.3, 4 or 5, form so-
-called 'restriction-modification systems'. A complelte listing of
all the these enzymes has been produced by R.J.Roberts; this list
is update annually.
MOTIF PS: PS00092 [LIVAC]-[LIVFYWA]-x-[DN]-P-P-[FYW]
GENES MJA: MJ0598 MJ1498
ECO: b2330(yfcB) b3262(yhdJ) b3387(dam) b4349(hsdM)
HIN: HI0209(dam) HI0513(hinDIIM) HI1392(hindIIIM)
HPY: HP0050(dpnA) HP0054 HP0478 HP0481 HP0910 HP1352
SYN: slr1378
STRUCTURES PDB: 1AQI 1AQJ 2ADM
DBLINKS University of Geneva ENZYME DATA BANK: 2.1.1.72
WIT (What Is There) Metabolic Reconstruction: 2.1.1.72
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