ENTRY       EC 2.1.1.67
NAME        Thiopurine S-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:thiopurine S-methyltransferase
REACTION    S-Adenosyl-L-methionine + a Thiopurine =
            S-Adenosyl-L-homocysteine + a Thiopurine S-methylether
SUBSTRATE   S-Adenosyl-L-methionine
            Thiopurine
PRODUCT     S-Adenosyl-L-homocysteine
            Thiopurine S-methylether
COMMENT     Also acts, more slowly, on thiopyrimidines and aromatic thiols.
            Not identical with EC 2.1.1.9.
DISEASE     MIM: 187680  Thiopurine S-methyltransferase; 6-mercaptopurine
                         sensitivity (3)
GENES       HSA: TPMT(Hs.85291)
DBLINKS     University of Geneva ENZYME DATA BANK: 2.1.1.67
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.67
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