ENTRY       EC 2.1.1.6
NAME        Catechol O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:catechol O-methyltransferase
REACTION    S-Adenosyl-L-methionine + Catechol =
            S-Adenosyl-L-homocysteine + Guaiacol
SUBSTRATE   S-Adenosyl-L-methionine
            Catechol
            Catecholamine
            (R)-(-)-Adrenaline
            Noradrenaline
PRODUCT     S-Adenosyl-L-homocysteine
            Guaiacol
COMMENT     The mammalian enzyme acts more rapidly on catecholamines such as
            adrenaline or noradrenaline than on catechols.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
DISEASE     MIM: 116790  Catechol-O-methyltransferase
GENES       HSA: COMT(Hs.89893)
STRUCTURES  PDB: 1VID  
DBLINKS     University of Geneva ENZYME DATA BANK: 2.1.1.6
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.6
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