ENTRY       EC 2.1.1.49
NAME        Amine N-methyltransferase
            Nicotine N-methyltransferase
            Tryptamine N-methyltransferase
            Arylamine N-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:amine N-methyltransferase
REACTION    S-Adenosyl-L-methionine + an Amine = S-Adenosyl-L-homocysteine +
            a Methylated amine
SUBSTRATE   S-Adenosyl-L-methionine
            Amine
            Tryptamine
            Aniline
            Nicotine
PRODUCT     S-Adenosyl-L-homocysteine
            Methylated amine
COMMENT     An enzyme of very broad specificity; many primary, secondary and
            tertiary amines can act as acceptors, including tryptamine,
            anilinem nicotine and a variety of drugs and other xenobiotics.
DBLINKS     University of Geneva ENZYME DATA BANK: 2.1.1.49
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.49
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