ENTRY       EC 2.1.1.44
NAME        Dimethylhistidine N-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:Nalpha,Nalpha-dimethyl-L-histidine
            $ Nalpha-methyltransferase
REACTION    S-Adenosyl-L-methionine + Nalpha,Nalpha-Dimethyl-L-histidine =
            S-Adenosyl-L-homocysteine +
            Nalpha,Nalpha,Nalpha-Trimethyl-L-histidine
SUBSTRATE   S-Adenosyl-L-methionine
            Nalpha,Nalpha-Dimethyl-L-histidine
            Nalpha-Methylhistidine
            Histidine
PRODUCT     S-Adenosyl-L-homocysteine
            Nalpha,Nalpha,Nalpha-Trimethyl-L-histidine
COMMENT     Methylhistidine and histidine can also act as methyl acceptors,
            trimethylhistidine being formed in both cases.
DBLINKS     University of Geneva ENZYME DATA BANK: 2.1.1.44
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.44
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