ENTRY       EC 2.1.1.4
NAME        Acetylserotonin N-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:N-acetylserotonin O-methyltransferase
REACTION    S-Adenosyl-L-methionine + N-Acetylserotonin =
            S-Adenosyl-L-homocysteine + N-Acetyl-5-methoxytryptamine
SUBSTRATE   S-Adenosyl-L-methionine
            N-Acetylserotonin
            Hydroxyindole
PRODUCT     S-Adenosyl-L-homocysteine
            N-Acetyl-5-methoxytryptamine
COMMENT     Some other hydroxyindoles also act as acceptor, more slowly.
PATHWAY     PATH: MAP00380  Tryptophan metabolism
DISEASE     MIM: 300015  Acetylserotonin methyltransferase
            MIM: 402500  Acetylserotonin methyltransferase (Y chromosome)
GENES       HSA: ASMT(HIOMT)
DBLINKS     University of Geneva ENZYME DATA BANK: 2.1.1.4
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.4
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