ENTRY       EC 2.1.1.28
NAME        Phenylethanolamine N-methyltransferase
            Noradrenalin N-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:phenylethanolamine N-methyltransferase
REACTION    S-Adenosyl-L-methionine + Phenylethanolamine =
            S-Adenosyl-L-homocysteine + N-Methylphenylethanolamine
SUBSTRATE   S-Adenosyl-L-methionine
            Phenylethanolamine
            Noradrenaline
PRODUCT     S-Adenosyl-L-homocysteine
            N-Methylphenylethanolamine
            (R)-(-)-Adrenaline
COMMENT     Acts on various phenylethanolamines; converts noradrenaline
            into adrenaline.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
DISEASE     MIM: 171190  Phenylethanolamine N-methyltransferase; ?Hypertension,
                         essential, 145500 (1)
MOTIF       PS: PS01100  L-I-D-I-G-S-G-P-T-[IV]-Y-Q-L-L-S-A-C
GENES       HSA: PNMT(PENT)
DBLINKS     University of Geneva ENZYME DATA BANK: 2.1.1.28
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.28
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