ENTRY       EC 2.1.1.13
NAME        5-Methyltetrahydrofolate--homocysteine S-methyltransferase
            Methionine synthase
            Tetrahydropteroylglutamate methyltramsferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     5-Methyltetrahydrofolate:L-homocysteine S-methyltransferase
REACTION    5-Methyltetrahydrofolate + L-Homocysteine = Tetrahydrofolate +
            L-Methionine
SUBSTRATE   5-Methyltetrahydrofolate
            L-Homocysteine
            5-Methyltetrahydropteroyl-L-glutamate
            5-Methyltetrahydropteroyltri-L-glutamate
            S-Adenosyl-L-methionine
PRODUCT     Tetrahydrofolate
            L-Methionine
            Tetrahydropteroyl-L-glutamate
            Tetrahydropteroyltri-L-glutamate
COFACTOR    Cobamide
            FAD
COMMENT     A cobamide-protein. The bacterial enzyme requires S-adenosyl-
            -L-methionine and reduced FAD. Acts on monoglutamate or
            triglutamate derivatives.
PATHWAY     PATH: MAP00271  Methionine metabolism
            PATH: MAP00670  One carbon pool by folate
DISEASE     MIM: 156570  5-methyltetrahydrofolate-homocysteine
                         methyltransferase 1; Methylcobalamin deficiency, cbl G
                         type (3)
GENES       ECO: b4019(metH)
            SYN: slr0212(metH)
            HSA: MTR
STRUCTURES  PDB: 1BMT  1MSK  
DBLINKS     University of Geneva ENZYME DATA BANK: 2.1.1.13
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.13
            SCOP (Structural Classificaion of Proteins): 2.1.1.13
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