ENTRY       EC 2.1.1.115
NAME        (R,S)-Tetrahydrobenzylisoquinoline N-methyltransferase
            Norreticuline N-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
REACTION    S-Adenosyl-L-methionine + (R,S)-Tetrahydrobenzylisoquinoline =
            S-Adenosyl-L-homocysteine + N-Methyl-(R,S)-tetrahydrobenzyl
            $isoquinoline
SUBSTRATE   S-Adenosyl-L-methionine
            (R,S)-Tetrahydrobenzylisoquinoline
PRODUCT     S-Adenosyl-L-homocysteine
            N-Methyl-(R,S)-tetrahydrobenzylisoquinoline
COMMENT     Broad substrate specificity for (R,S)-Tetrahydrobenzylisoquinolines;
            Including Coclaurine, Norcoclaurine, Isococlaurine, Norarmepavine,
            Norreticuline and Tetrahydropapaverine.
            Both R- and S-enantiomers are methylated.
            Partcipates in the pathway leading to Benzylisoquinoline alkaloid
            synthesis in plants. The physiological substrate is likely to be
            Coclaurine.
            Was termed Norreticuline N-methyltransferase, however Norreticuline
            has not been found to cccur in nature and that name does not
            reflects the broad specificity of the enzyme.
DBLINKS     University of Geneva ENZYME DATA BANK: 2.1.1.115
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.115
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