ENTRY       EC 1.5.3.9
NAME        Reticuline oxidase
            Berberine-bridge-forming enzyme
            Tetrahydroprotoberberine synthase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With oxygen as acceptor
SYSNAME     (S)-Reticuline:oxygen oxidoreductase (methylene-bridge-forming)
REACTION    (S)-Reticuline + O2 = (S)-Scoulerine + H2O2
SUBSTRATE   (S)-Reticuline
            O2
PRODUCT     (S)-Scoulerine
            H2O2
COMMENT     Acts on (S)-reticuline and related compounds, converting the
            N-methyl group into the methylene bridge ('berberine bridge') of
            (S)-tetrahydroprotoberberines.
MOTIF       PS: PS00862  P-x(10)-[DE]-[LIVM]-x(3)-[LIVM]-x(9)-[LIVM]-x(3)-[GSA]-
                         [GST]-G-H
DBLINKS     University of Geneva ENZYME DATA BANK: 1.5.3.9
            WIT (What Is There) Metabolic Reconstruction: 1.5.3.9
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