ENTRY       EC 1.3.3.8
NAME        Tetrahydroberberine oxidase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With oxygen as acceptor
SYSNAME     (S)-Tetrahydroberberine:oxigen oxidoreductase
REACTION    (S)-Tetrahydroberberine + 2 O2 = Berberine + 2 H2O
SUBSTRATE   (S)-Tetrahydroberberine
            O2
PRODUCT     Berberine
            H2O2
COMMENT     The enzyme from berberis sp.  (prevously listed as EC 1.5.3.8) is
            a flavoprotein; that form Coptis japonica is not.
            (R)-Tetrahydroberberines are not oxidized.
DBLINKS     University of Geneva ENZYME DATA BANK: 1.3.3.8
            WIT (What Is There) Metabolic Reconstruction: 1.3.3.8
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