ENTRY       EC 1.3.3.1
NAME        Dihydroorotate oxidase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With oxygen as acceptor
SYSNAME     (S)-Dihydroorotate:oxygen oxidoreductase
REACTION    (S)-Dihydroorotate + O2 = Orotate + H2O2
SUBSTRATE   (S)-Dihydroorotate
            O2
            Ferricyanide
PRODUCT     Orotate
            H2O2
COFACTOR    FAD
            FMN
COMMENT     A flavoprotein (FAD, FMN). Ferricyanide can act as acceptor.
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
MOTIF       PS: PS00911  [STA]-[LIVMSTA]-T-x(3)-[QR]-x-G-N-[PAD]-x-P-R-
                         [LIVMFYWQ]
            PS: PS00912  [LIVM](2)-[GS]-x-G-G-[LIVM]-x-[STG]-x(3)-A-x(6)-G-A
GENES       MJA: MJ0654(pyrD)
            MTH: MTH1213
            ECO: b0945(pyrD)
            HIN: HI1401(pyrD)
            BSU: pyrD(pyrDI)
            SYN: slr1418(pyrD)
            SCE: YKL216W(URA1)
            HSA: DHODH(Hs.1151)
STRUCTURES  PDB: 1DOR  
DBLINKS     University of Geneva ENZYME DATA BANK: 1.3.3.1
            WIT (What Is There) Metabolic Reconstruction: 1.3.3.1
///