ENTRY       EC 1.2.3.3
NAME        Pyruvate oxidase
            Pyruvic oxidase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With oxygen as acceptor
SYSNAME     Pyruvate:oxygen 2-oxidoreductase (phosphorylating)
REACTION    Pyruvate + Orthophosphate + O2 + H2O = Acetyl phosphate + CO2 +
            H2O2
SUBSTRATE   Pyruvate
            Orthophosphate
            O2
            H2O
PRODUCT     Acetyl phosphate
            CO2
            H2O2
COFACTOR    FAD
            Thiamine diphosphate
COMMENT     A flavoprotein (FAD) requiring thiamine diphosphate. Sequence and
            functional similarity to acetolactate synthase (EC 4.1.3.18);
            Nature, 1988, 331, 360-362. Evolved from a common ancestor.
PATHWAY     PATH: MAP00620  Pyruvate metabolism
MOTIF       PS: PS00187  [LIVMF]-[GSA]-x(5)-P-x(4)-[LIVMFYW]-x-[LIVMF]-x-G-D-
                         [GSA]-[GSAC]
STRUCTURES  PDB: 1POW  1POX  
DBLINKS     University of Geneva ENZYME DATA BANK: 1.2.3.3
            WIT (What Is There) Metabolic Reconstruction: 1.2.3.3
            SCOP (Structural Classificaion of Proteins): 1.2.3.3
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