ENTRY       EC 1.2.1.51
NAME        Pyruvate dehydrogenase (NADP+)
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Pyruvate:NADP+ 2-oxidoreductase (CoA-acetylating)
REACTION    Pyruvate + CoA + NADP+ = Acetyl-CoA + CO2 + NADPH
SUBSTRATE   Pyruvate
            CoA
            NADP+
            FAD
            Methyl viologen
PRODUCT     Acetyl-CoA
            CO2
            NADPH
INHIBITOR   O2
COMMENT     The Euglena enzyme can also use FAD or methyl viologen as
            acceptor, more slowly. The enzyme is inhibited by oxygen.
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00620  Pyruvate metabolism
DBLINKS     University of Geneva ENZYME DATA BANK: 1.2.1.51
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.51
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