ENTRY       EC 1.2.1.12
NAME        Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)
            Triosephosphate dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-Glyceraldehyde-3-phosphate:NAD+ oxidoreductase(phosphorylating)
REACTION    D-Glyceraldehyde 3-phosphate + Orthophosphate + NAD+ =
            3-Phospho-D-glyceroyl phosphate + NADH
SUBSTRATE   D-Glyceraldehyde 3-phosphate
            D-Glyceraldehyde
            Orthophosphate
            Thiol
            NAD+
PRODUCT     3-Phospho-D-glyceroyl phosphate
            NADH
COMMENT     Also acts very slowly on D-glyceraldehyde and some other
            aldehydes; thiols can replace phosphate.
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00472  D-Arginine and D-ornithine metabolism
DISEASE     MIM: 138400  Glyceraldehyde-3-phosphate dehydrogenase
MOTIF       PS: PS00071  [ASV]-S-C-[NT]-T-x(2)-[LIM]
            PS: PS00342  [SAGCN]-[RKH]-[LIVMAF]>
GENES       MJA: MJ1146
            MTH: MTH1009
            ECO: b1416(gapC_2) b1417(gapC_1) b1779(gapA)
            HIN: HI0001(gapA)
            HPY: HP0921 HP1346
            BSU: gap gapB
            MGE: MG301(gapA)
            MPN: A05_orf337(gapA)
            SYN: sll1342(gap2) slr0884(gap1)
            SCE: YGR192C(TDH3) YJL052W(TDH1) YJR009C(TDH2) YOL059W(GPD2)
            HSA: GAPD(Hs.74456)
STRUCTURES  PDB: 1GAD  1GAE  1GD1  1GGA  1GPD  1GYP  1HDG  3DBV  3GPD  2DBV  
                 4DBV  4GPD  1DBV  1CER  2GD1  
DBLINKS     University of Geneva ENZYME DATA BANK: 1.2.1.12
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.12
            SCOP (Structural Classificaion of Proteins): 1.2.1.12
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