ENTRY       EC 1.17.4.2
NAME        Ribonucleoside-triphosphate reductase
            Ribonucleotide reductase
CLASS       Oxidoreductases
            Acting on -CH2- groups
            With a disulfide as acceptor
SYSNAME     2'-Deoxyribonucleoside-triphosphate:oxydized-thioredoxin
            $ 2'-oxidoreductase
REACTION    2'-Deoxyribonucleoside triphosphate + Oxidized thioredoxin +
            H2O = Ribonucleoside triphosphate + Reduced thioredoxin
SUBSTRATE   2'-Deoxyribonucleoside triphosphate
            Oxidized thioredoxin
            H2O
PRODUCT     Ribonucleoside triphosphate
            Reduced thioredoxin
COFACTOR    Cobamide coenzyme
            Iron
            ATP
COMMENT     Requires a cobamide coenzyme and ATP.  Nonheme diiron enzyme.
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00240  Pyrimidine metabolism
MOTIF       PS: PS00850  [STIV]-x-R-[VT]-[CSA]-G-Y-x-[GACV]
GENES       MJA: MJ0832
            MTH: MTH1539
            ECO: b4238(nrdD)
            HIN: HI0075(nrdD)
DBLINKS     University of Geneva ENZYME DATA BANK: 1.17.4.2
            WIT (What Is There) Metabolic Reconstruction: 1.17.4.2
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