ENTRY       EC 1.15.1.1
NAME        Superoxide dismutase
CLASS       Oxidoreductases
            Acting on superoxide radicals as acceptor
SYSNAME     Superoxide:superoxide oxidoreductase
REACTION    O2.- + O2.- + 2 H+ = O2 + H2O2
SUBSTRATE   O2.-
            H+
PRODUCT     O2
            H2O2
COFACTOR    Copper
            Zinc
            Manganese
            Iron
COMMENT     A metalloprotein; also known as erythrocuprein, hemocuprein or
            cytocuprein. Enzymes from most eucaryotes contain both copper and
            zinc; those from mitochondria and most procaryotes contain
            manganese or iron.
DISEASE     MIM: 147450  Superoxide dismutase-1, soluble; Amytrophic lateral
                         sclerosis, due to SOD1 deficiency, 105400 (3)
            MIM: 147460  Superoxide dismutase-2, mitochondrial
            MIM: 185490  Superoxide dismutase-3, extracellular
MOTIF       PS: PS00087  [GA]-[IFAT]-H-[LIVF]-H-x(2)-[GP]-[SDG]-x-[STAGD]
            PS: PS00088  D-x-W-E-H-[STA]-[FY](2)
            PS: PS00332  G-[GN]-[SGA]-G-x-R-x-[SGA]-C-x(2)-[IV]
GENES       MTH: MTH160(sod)
            ECO: b1646(sodC) b1656(sodB) b3908(sodA)
            HIN: HI1088(sodA)
            HPY: HP0389(sodB)
            BSU: sodA(yqgD) yojM
            SYN: slr1516(sodB)
            SCE: YHR008C(SOD2) YJR104C(SOD1)
            HSA: SOD1(ALS) SOD2(Hs.73830) SOD3(Hs.2420)
STRUCTURES  PDB: 0SDE  1COB  1ISA  1ISB  1ISC  1JCV  1JCW  1MNG  1MSD  1SDA  
                 1SDY  1SOS  1SPD  1SRD  1SXA  1SXB  1SXC  1VAR  1XSO  1YSO  
                 2SOD  3MDS  3SDP  3SOD  4SOD  1ABM  1IDS  
DBLINKS     University of Geneva ENZYME DATA BANK: 1.15.1.1
            WIT (What Is There) Metabolic Reconstruction: 1.15.1.1
            SCOP (Structural Classificaion of Proteins): 1.15.1.1
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