ENTRY EC 1.14.17.1
NAME Dopamine beta-monooxygenase
Dopamine beta-hydroxylase
CLASS Oxidoreductases
Acting on paired donors with incorporation of molecular oxygen
With ascorbate as one donor, and incorporation of one atom of
oxygen
SYSNAME 3,4-Dihydroxyphenetylamine,ascorbate:oxygen oxidoreductase
(beta-hydroxylating)
REACTION 3,4-Dihydroxyphenethylamine + Ascorbate + O2 = Noradrenaline +
Dehydroascorbate + H2O
SUBSTRATE 3,4-Dihydroxyphenethylamine
Ascorbate
O2
PRODUCT Noradrenaline
Dehydroascorbate
H2O
COFACTOR Fumarate
Copper
PQQ
COMMENT A copper protein. Stimulated by fumarate. Formerly EC 1.14.2.1.
PQQ: van der Meer,R.A., Jongejan,J.A., Duine,J.A. FEBS Lett. 231,
303-307 (1988).
PATHWAY PATH: MAP00350 Tyrosine metabolism
DISEASE MIM: 223360 Dopamine-beta-hydroxylase; Dopamine-beta-hydroxylase
deficiency (1)
MOTIF PS: PS00084 H-H-M-x(2)-F-x-C
PS: PS00085 H-x-F-x(4)-H-T-H-x(2)-G
GENES HSA: DBH(Hs.2301)
DBLINKS University of Geneva ENZYME DATA BANK: 1.14.17.1
WIT (What Is There) Metabolic Reconstruction: 1.14.17.1
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