ENTRY       EC 1.14.13.39
NAME        Nitric-oxide synthase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming)
REACTION    L-Arginine + n NADPH + m O2 = Citrulline + Nitric oxide + n NADP+
SUBSTRATE   L-Arginine
            NADPH
            O2
PRODUCT     Citrulline
            Nitric oxide
            NADP+
INHIBITOR   Ngamma-Nitro-L-arginine
            Ngamma-Nitro-L-arginine methyl ester
            Ngamma-Monomethyl-L-arginine
COFACTOR    Calcium
COMMENT     The enzyme in brain, but not that induced in lung or liver by
            endotoxin, requires Ca2+. The stoichiometry is not clear, but
            may involve a two-electron and a one-electron oxidation step.
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
DISEASE     MIM: 163729  Nitric oxide synthase 3 (endothelial cell);
                         Hypertension, pregnancy-induced (2)
            MIM: 163730  Nitric oxide synthase 2A (inducible, hepatocytes)
            MIM: 163731  Nitric oxide synthase 1, neuronal
GENES       HSA: NOS1(NOS) NOS2A(NOS2) NOS3(ECNOS)
DBLINKS     University of Geneva ENZYME DATA BANK: 1.14.13.39
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.39
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