ENTRY EC 1.14.13.38
NAME Anhydrotetracycline monooxygenase
ATC oxygenase
CLASS Oxidoreductases
Acting on paired donors with incorporation of molecular oxygen
With NADH or NADPH as one donor, and incorporation of one atom of
oxygen
SYSNAME Anhydrotetracycline,NADPH:oxygen oxidoreductase (6-hydroxylating)
REACTION Anhydrotetracycline + NADPH + O2 = 12-Dehydrotetracycline +
NADP+ + H2O
SUBSTRATE Anhydrotetracycline
NADPH
O2
PRODUCT 12-Dehydrotetracycline
NADP+
H2O
COMMENT Involved in the biosynthesis of the antibiotics tetracyclines in
Streptomyces sp.
DBLINKS University of Geneva ENZYME DATA BANK: 1.14.13.38
WIT (What Is There) Metabolic Reconstruction: 1.14.13.38
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