ENTRY       EC 1.14.12.11
NAME        Toluene dioxygenase
            Toluene 1,2-dioxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of two atoms
            of oxygen into one donor
SYSNAME     Toluene,NADH:oxygen oxidoreductase (1,2-hydroxylating)
REACTION    Toluene + NADH + O2 =
            (1S,2R)-3-Methylcyclohexa-3,5-diene-1,2-diol + NAD+
SUBSTRATE   Toluene
            NADH
            O2
PRODUCT     (1S,2R)-3-Methylcyclohexa-3,5-diene-1,2-diol
            NAD+
COMMENT     A system, containing a reductase which is an iron-sulfur
            flavoprotein (FMN), an iron-sulfur oxygenase, and a ferredoxin.
            Some other aromatic compounds, including ethylbenzene, 4-xylene
            and some halogenated toluenes, are converted into the
            corresponding cis-dihydrodiols.
MOTIF       PS: PS00570  C-x-H-R-G-x(8)-G-N-x(5)-C-x-[FY]-H
DBLINKS     University of Geneva ENZYME DATA BANK: 1.14.12.11
            WIT (What Is There) Metabolic Reconstruction: 1.14.12.11
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