ENTRY       EC 1.14.11.6
NAME        Thymine dioxygenase
            Thymine 7-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With 2-oxoglutarate as one donor, and incorporation of one atom
            each of oxygen into both donors
SYSNAME     Thymine,2-oxoglutarate:oxygen oxidoreductase (7-hydroxylating)
REACTION    Thymine + 2-Oxoglutarate + O2 = 5-Hydroxymethyluracil +
            Succinate + CO2
SUBSTRATE   Thymine
            2-Oxoglutarate
            O2
PRODUCT     5-Hydroxymethyluracil
            Succinate
            CO2
COFACTOR    Iron
            Ascorbate
COMMENT     Requires Fe2+ and ascorbate. Also acts on 5-hydroxymethyluracil
            to oxidize its -CH2OH group first to -CHO and then to -COOH.
DBLINKS     University of Geneva ENZYME DATA BANK: 1.14.11.6
            WIT (What Is There) Metabolic Reconstruction: 1.14.11.6
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